Abstract: Vision impairment caused by pathologic myopia (PM) is a global public health concern. Changes in the morphological characteristics of the optic disc region can serve as an early warning for the onset and progression of PM. Alterations such as optic disc tilting, peripapillary atrophy of the retina and choroid, and parapapillary choroidal cavitations are associated with the development of posterior staphyloma. Pathologic changes in the optic disc in PM often coexist with PM-related macular degeneration, with the progression and expansion of atrophic areas around the optic disc and the peripapillary choroid indicating the development of myopic maculopathy. Insufficient blood flow in the optic disc area and its surroundings may be a reason for the morphological and functional changes in PM. Timely and accurate identification of such characteristic imaging biomarkers is crucial for the prevention, control, and treatment of PM. (Int Rev Ophthalmol, 2024, 48: 93-98)

Key words: pathologic myopia, optic disc, peripapillary, imaging biomarker